The Royal Palace of Portici (Reggia di Portici or Palazzo Reale di Portici; Neapolitan: Reggia ‘e Puortece) is a former royal palace in Portici, Southeast of Naples along the coast, in the region of Campania, Italy. Today it is the home of the Orto Botanico di Portici, a Botanic Gardens are operated by the University of Naples Federico II. These gardens were once part of the large royal estate that included an English garden, a zoo and formal parterres.

On 3 July 1735 at the age of 18, Infante Charles of Spain was crowned the King of Naples and Sicily. He had taken control of the two kingdoms by military force opposing the powerful Charles VI, Holy Roman Emperor. In 1738, Charles and his consort Princess Maria Amalia of Saxony were favourably impressed with the area of Portici when they visited the villa of Emmanuel Maurice, the Duke of Elbeuf. The couple commissioned this palace in Portici to serve not only as a private residence, but as a place to receive foreign officials travelling to the kingdom.

Work began at the end of 1738 under the direction of Antonio Canevari. Canevari had helped the royal couple in construction of the Neapolitan Palace of Capodimonte. The interiors of the Palace of Portici were frescoed by Giuseppe Bonito, while the gardens were decorated with marble sculptures by Joseph Canart.

Portions of ancient Roman villas and noble residences were discovered in preparing the foundations of the palace, and excavation of the area revealed numerous works of art, among them temple with 24 marble columns. This discovery was put in the Museum of Portici, built for the occasion, and annexed to the Accademia Ercolanese. The museum was founded by Charles in 1755 also to house the findings from the excavations of Herculaneum.

Since the new royal palace was not large enough to house the whole court, it stimulated construction of other grand residences in the neighborhood, 122 of which are now known as the Vesuvian Villas. This also led to the expansion of the Palace of Capodimonte. Charles and his wife kept the Portici Palace as their summer residence and seven of their twelve children were born there.